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. Author manuscript; available in PMC: 2022 Feb 6.
Published in final edited form as: Annu Rev Physiol. 2019 Sep 27;82:391–412. doi: 10.1146/annurev-physiol-021119-034602

Figure 2.

Figure 2

Lung circadian gene expression is specialized for immune regulation. Depicted is a functional enrichment analysis of the human and mouse lung circadian transcriptome synthesized from recently published data (74, 80). Enriched functional enrichment terms are positioned along a 24-h time line expressed in units of zeitgeber time (ZT), where ZT0 represents the onset of daytime (yellow) and Z12 the onset of nighttime (blue). Functional enrichment terms relating to immune function are colored red. In both mice and humans, immune pathways are predominantly enriched at the gene expression level during their respective natural rest phases.