Table 1:

Growth inhibition (%) of 5-pyridinyl-1,2,4-triazole derivatives 5a-d, 6a-d, 7a-d, 10a-d, and 11a-d

Cpd	R	HCT116	HT-29	K562	KG-1	A-498	Caki-1
5a	Methyl	20.12	34.19	18.25	55.94	45.28	34.69
5b	Ethyl	2.15	9.34	1.58	7.34	4.13	1.06
5c	Allyl	16.25	21.25	2.95	15.36	11.36	3.25
5d	Phenyl	78.51	80.48	72.73	67.19	89.34	94.8
6a	Methyl	60.14	68.34	40.12	84.17	99.81	98.14
6b	Ethyl	21.35	9.15	4.09	17.28	5.26	2.06
6c	Allyl	2.07	41.28	16.12	5.91	11.06	8.62
6d	Phenyl	3.56	1.09	8.34	11.25	4.36	7.68
7a	Methyl	54.36	71.36	44.94	63.15	45.34	50.82
7b	Ethyl	6.35	18.64	10.36	3.64	22.34	8.91
7c	Allyl	90.49	95.48	86.37	94.18	97.67	95.38
7d	Phenyl	24.51	9.64	15.14	34.91	4.67	1.65
10a	Methyl	32.36	54	16	72.08	31.84	48.19
10b	Ethyl	1.03	8.34	14.29	7.12	1.67	9.34
10c	Allyl	44.13	25.34	36.08	61.95	44.85	50.21
10d	Phenyl	29.34	42.67	39.13	50.94	56.91	61.85
11a	Methyl	18.03	47.91	54.09	24.11	55.61	75.16
11b	Ethyl	1.85	1.22	8.67	5.91	1.18	12.09
11c	Allyl	80.46	70.67	90.14	87.46	97.08	94.81
11d	Phenyl	45.36	37.92	19.6	47.34	72.54	66.94