Skip to main content
. 2022 Feb 7;38(9):110428. doi: 10.1016/j.celrep.2022.110428

Figure 4.

Figure 4

Structural basis of neutralizing antibody escape by Omicron

(A) Surface diagram of class 1 and 2 antibodies bound to RBD. Left: VH3-53-derived antibodies with CB6 as an example (PDB: 7C01). Middle: VH1-58/VK3-20-derived antibodies with A23-58.1 (PDB: 7LRS)-binding mode shown. Right: VH1-2-derived antibody with 2-15 (PDB: 7L57)-binding mode shown. Mutations in Omicron RBD are colored in red.

(B) Surface diagram of the class 3 and 4 antibodies bound to Omicron RBD, antibody REGN10987 (PDB: 6XDG), S309 (PDB: 6WPT), 10–40 (PDB: 7SD5), and DH1047 (PDB: 7LD1) are shown.

(C) Cartoon diagrams of the Omicron and WT NTDs in complex with antigenic supersite-directed antibodies and 5-7 (PDB: 7RW2). Omicron mutations are shown as red spheres. See also Figure S5.