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Nitration of Tyr 56 in Hsp90 by peroxynitrite induces PC12 cells apoptosis by activation of P2X7R and downstreamactivationof PTEN. Nitration of Hsp90 at Tyr 56 by peroxynitrite leads to the activation of the P2X7R complex, inducing a calcium influx that triggers the simultaneous activation of p38 and JNK 54, and the inhibition of the PI3K/Akt pathway through activation of PTEN, ultimately inducing PC12 cell apoptosis.
