Fig. 3.

Treatment of Au@P-NPs and Au-NPs on a mice obesity model induced by HFD. We fed the mice either a CD or HFD and treated with daily dose of Au@P-NPs and Au-NPs at the concentration of 10 ​mg/kg body weight for 8 weeks. (a) Body weight in grams. (b) Body weight in percentage. (c) Energy consumption. (d) Weight of eWAT, rWAT, mWAT and iWAT together with iBAT, which indicated the level of fat storage, in adipose tissues. (e) Liver weight. (f) Content of liver triglycerides. (g) Content of triglycerides in the blood after 6 ​h of starvation, an indicator of hyperlipidemia. At week 5, animals were placed in metabolic cages and assessed (h) faecal energy excretion and (i) energy expenditure. The connection between metabolic rate and body mass was normalized using the metabolic body size (ie, body mass^0.75) and measured (j) energy partitioning and (k) interscapular temperature. (a, i) Two-way frequent measurements ANOVA with BPHT. (b–h, k) One-way frequent measurements ANOVA with BPHT. ∗P ​< ​0.05, ∗∗P ​< ​0.01 and ∗∗∗P ​< ​0.001 for CD against HFD; ^$P ​< ​0.05, ^$$P ​< ​0.01 and ^$$$P ​< ​0.001 for Au@P-NPs against HFD.