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. 2022 Feb 1;18:101348. doi: 10.1016/j.tranon.2022.101348

Fig. 5.

Fig 5

The effect of PtPz4, PtPz6, cisPt, and anti-MUC1 on p53 mRNA expression in DLD-1 and HT-29 colon cancer cells. The cells were incubated for 24 h with PtPz4 (10 μM), PtPz6 (10 μM), cisPt (10 μM), anti-MUC1 (5 μg/mL), PtPz4 + anti-MUC1 (10 μM + 5 μg/mL), PtPz6 + anti-MUC1 (10 μM + 5 μg/mL), and cisPt + anti-MUC1 (10 μM + 5 μg/mL). p53 gene expression was assessed by RT-PCR. The result is presented as a relative fold change in mRNA expression of gene in comparison of gene in control where expression was set as 1. ±SD are the mean of triplicate cultures. ** P < 0.01; *** P < 0.001 compared to untreated control; ##P < 0.01 compared to PtPz4 monotherapy; ΔΔΔP < 0.001 compared to PtPz6 monotherapy; †P < 0.05 compared to cisPt monotherapy; ‡‡P < 0.01 compared to anti-MUC1 monotherapy.