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. 2022 Jan 24;8:812278. doi: 10.3389/fmed.2021.812278

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Copyright © 2022 Geng, Huang, Li, Shen, Xue and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Down-regulation of FN1 suppressed THCA cell migration and invasion in vitro. (A) qRT-PCR showing the efficient depletion of FN1 expression and the expression of CD276 in B-CPAP and KTC-1 cells compared with siNC transfection. Representative photo-images (left) and histograms (right) of the effect of siFN1 on the clone formation (B) and migration (D) of B-CPAP and KTC-1 cells. (C) The proliferative ability of B-CPAP and KTC-1 cells after transfection was evaluated by CCK-8 assay. *p < 0.05, **p < 0.001.