Table 1.
Clinical laboratory results.
| Patient | Measure | Reference range | Illness Day 4, Hospital Day 1 | Illness Day 6, Hospital Day 3 | Illness Day 8, Hospital Day 5 | Illness Day 10, Hospital Day 7 |
|---|---|---|---|---|---|---|
| Case 1 | White-cell count (*109/L) | 3.5–9.5 | 8.83 | 14.66 | 11.76 | 7.94 |
| Red-cell count (1012/L) | 3.8–5.1 | 4.49 | 3.74 | 4.1 | 3.98 | |
| Absolute neutrophil count (*109/L) | 1.8–6.3 | 8.18 | 12.98 | 9.92 | 6.2 | |
| Absolute lymphocyte count (*109/L) | 1.1–3.2 | 0.44 | 1.02 | 1.22 | 1.23 | |
| Platelet count (*109/L) | 125.0–350.0 | 156 | 171 | 234 | 254 | |
| Hemoglobin (g/L) | 115.0–150.0 | 132 | 111 | 124 | 135 | |
| Hematocrit (%) | 35.0–45.0 | 39.3 | 34.3 | 36.9 | 40.2 | |
| Sodium (mmol/L) | 136.0–145.0 | 133.3 | 136.8 | / | / | |
| Potassium (mmol/L) | 3.5–5.1 | 3.47 | 4.41 | 3.69 | 4.17 | |
| Chloride (mmol/L) | 99.0–110.0 | 95.4 | 103.4 | / | / | |
| Calcium (mmol/L) | 2.20–2.55 | 2.19 | 2.14 | / | / | |
| Bicarbonate radical (mmol/L) | 22.0–29.0 | 20.7 | 22.7 | 26.6 | 22.2 | |
| Glucose (mmol/L) | 3.9–6.1 | 14.18 | 5.6 | 6.1 | / | |
| Blood urea nitrogen (mmol/L) | 2.6–7.5 | 6.26 | 10.10 | 7.93 | 11.75 | |
| Creatinine (μmol/L) | 45–84 | 79 | 63 | 59 | 69 | |
| Total protein (g/L) | 64.0–83.0 | 73.3 | 65.9 | 72 | 67.2 | |
| Albumin (g/L) | 35.0–52.0 | 36.3 | 30.4 | 28.9 | 31.5 | |
| Total bilirubin (μmol/L) | ≤ 21.0 | 18.6 | 4.4 | 3.4 | 5.7 | |
| Procalcitonin (ng/ml) | 0.02–0.05 | 0.6 | / | / | 0.33 | |
| Alanine aminotransferase (U/L) | ≤ 33 | 43 | 32 | 80 | 36 | |
| Aspartate aminotransferase (U/L) | ≤ 32 | 231 | 78 | 79 | 130 | |
| Alkaline phosphatase (U/L) | 35–105 | 106 | 85 | 98 | 86 | |
| Fibrinogen (g/L) | 2.0–4.0 | 5.93 | 3.22 | / | / | |
| Lactate dehydrogenase (g/L) | 135.0–214.0 | 764 | 688 | 629 | 550 | |
| Prothrombin time (s) | 11.5–14.5 | 13.4 | 13.4 | / | / | |
| International normalized ratio | 0.8–1.2 | 1.01 | 1.03 | / | / | |
| Creatine kinase (U/L) | ≤ 190 | 1186 | 846 | 647 | 274 | |
| Venous lactate (mmol/L) | 0.5–2.2 | / | 1.77 | / | 1.82 | |
| Case 2 | White-cell count (*109/L) | 3.5–9.5 | 5.16 | 9.36 | 7.81 | 4.87 |
| Red-cell count (1012/L) | 3.8–5.1 | 3.25 | 3.79 | 4.3 | 4.1 | |
| Absolute neutrophil count (*109/L) | 1.8–6.3 | 4.65 | 8.08 | 7.16 | 5.3 | |
| Absolute lymphocyte count (*109/L) | 1.1–3.2 | 0.47 | 0.64 | 0.38 | 0.98 | |
| Platelet count (*109/L) | 125.0–350.0 | 91 | 83 | 61 | 110 | |
| Hemoglobin (g/L) | 130.0–175.0 | 98 | 111 | 125 | 134 | |
| Hematocrit (%) | 40.0–50.0 | 29.7 | 34.2 | 38.6 | 42 | |
| Sodium (mmol/L) | 136.0–145.0 | 138.8 | 137.8 | / | 139.3 | |
| Potassium (mmol/L) | 3.5–5.1 | 3.86 | 3.97 | 4.08 | 4.18 | |
| Chloride (mmol/L) | 99.0–110.0 | 108.9 | 107.0 | / | / | |
| Calcium (mmol/L) | 2.20–2.55 | 2.08 | 1.95 | / | / | |
| Bicarbonate radical (mmol/L) | 22.0–29.0 | 17.9 | 22.8 | 26.6 | 25.7 | |
| Glucose (mmol/L) | 3.9–6.1 | 8.49 | / | 5.5 | / | |
| Blood urea nitrogen (mmol/L) | 3.6–9.5 | 8.14 | 7.7 | 5.68 | 5.9 | |
| Creatinine (μmol/L) | 59–104 | 83 | 76 | 72 | 77 | |
| Total protein (g/L) | 64.0–83.0 | 63.4 | 61.7 | 69.5 | 68.4 | |
| Albumin (g/L) | 35.0–52.0 | 34.4 | 30.1 | 31.2 | 33.8 | |
| Total bilirubin (μmol/L) | ≤ 26.0 | 5.8 | 4.9 | 4.3 | 6.9 | |
| Procalcitonin (ng/ml) | 0.02–0.05 | 0.03 | / | / | / | |
| Alanine aminotransferase (U/L) | ≤ 33 | 28 | 41 | 80 | 85 | |
| Aspartate aminotransferase (U/L) | ≤ 32 | 93 | 34 | 44 | 36 | |
| Alkaline phosphatase (U/L) | 40–130 | 45 | 42 | 52 | 51 | |
| Fibrinogen (g/L) | 2.0–4.0 | 3.94 | / | 3.87 | / | |
| Lactate dehydrogenase (g/L) | 135.0–214.0 | 586 | 459 | 501 | 334 | |
| Prothrombin time (s) | 11.5–14.5 | 14.2 | 15.5 | 14.6 | 12 | |
| International normalized ratio | 0.8–1.2 | 1.09 | / | / | / | |
| Creatine kinase (U/L) | ≤ 190 | 586 | 687 | 423 | 211 | |
| Venous lactate (mmol/L) | 0.5–2.2 | 1.41 | / | 1.23 | / |