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. 2022 Jan 24;11:790912. doi: 10.3389/fonc.2021.790912

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Copyright © 2022 Chen, Ma, Yan, Wang, Ding, Guo, Ma, Chen and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FBXO22 promotes cell cycle progression. (A) Network diagram of FBXO22-binding proteins obtained from the STRING database. (B) Based on the corresponding genes of the FBXO22-binding proteins, their associated biological processes were investigated using Gene Ontology (GO) enrichment analysis. (C) Growth of wild-type and FBXO22-overexpressing A549 cells. (D) CDK4 expression in wild-type and FBXO22-overexpressing A549 cells. (E) Western blot analysis of PTEN protein levels and polyubiquitination in A549 cells stably expressing FBXO22, transfected with SH scramble or sh-FBXO22. ^*** p < 0.001.