Table 2.

Accuracy of Pathology, Molecular Tests, and Parallel Test (Positive Result for Either of the Two Assays) for the Diagnosis of Lymph Node Tuberculosis Against a Composite Reference Standard

Test	Sample	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	AUC
Pathology	All	94.5 (90.9–96.9)	97.2 (85.5–99.9)	99.6 (97.7–100.0)	71.4 (56.7–83.4)	0.96 (0.93–0.98)
	Tissue	96.6 (90.4–99.3)	100.0 (69.2–100.0)	100.0 (95.8–100.0)	76.9 (46.2–95.0)	0.98 (0.93–1.00)
	CNB	93.3 (88.4–96.6)	96.2 (80.4–99.9)	99.4 (96.5–100.0)	69.4(51.9–83.7)	0.95 (0.91–0.97)
Molecular test	All	73.1 (67.2–78.5)	100.0 (90.3–100.0)	100.0 (98.0–100.0)	34.6 (25.6–44.6)	0.87 (0.82–0.90)
	Tissue	67.1 (56.2–76.7)	100.0 (69.2–100.0)	100.0 (93.9–100.0)	25.6 (13.0–42.1)	0.84 (0.75–0.90)
	CNB	76.4 (69.1–82.6)	100.0 (86.8–100.0)	100.0 (97.1–100.0)	40.0 (28.0–52.9)	0.88 (0.83–0.92)
Parallel test	All	98.4 (96.0–99.6)	97.2 (85.5–99.9)	99.6 (97.8–100.0)	89.7 (75.8–97.1)	0.98 (0.95–0.99)
	Tissue	96.6 (90.4–99.3)	100.0 (69.2–100.0)	100.0 (95.8–100.0)	76.9 (46.2–95.0)	0.98 (0.93–1.00)
	CNB	99.4 (96.7–100.0)	96.2 (80.4–99.9)	99.4 (96.7–100.0)	96.2 (80.4–99.9)	0.98 (0.95–0.99)

Abbreviations: PPV, positive predictive value; NPV, negative predictive value; AUC, area under the curve; CNB, core needle biopsy.