Table 3.
Univariate analysis of factor associated with clinical outcomes.
| Item | Clinical pregnancy | Live birth | Miscarriage | |||
|---|---|---|---|---|---|---|
| OR,95%CI | P | OR,95%CI | P | OR,95%CI | P | |
| Female age | 0.94 (0.93, 0.94) | <0.0001 | 0.93 (0.92, 0.93) | <0.0001 | 1.10 (1.09, 1.11) | <0.0001 |
| BMI | 1.01 (1.00, 1.02) | 0.0006 | 1.00 (0.99, 1.01) | 0.9242 | 1.04 (1.03, 1.05) | <0.0001 |
| Duration of infertility(year) | 0.97 (0.96, 0.97) | <0.0001 | 0.97 (0.96, 0.97) | <0.0001 | 1.05 (1.04, 1.06) | <0.0001 |
| Infertility type | ||||||
| Primary Infertility | Ref. | Ref. | Ref. | |||
| Secondary Infertility | 0.86 (0.83, 0.90) | <0.0001 | 0.87 (0.83, 0.90) | <0.0001 | 1.35 (1.25, 1.46) | <0.0001 |
| Basal AMH(ng/ml) | 1.05 (1.04, 1.07) | <0.0001 | 1.08 (1.07, 1.10) | <0.0001 | 0.96 (0.94, 0.98) | 0.0008 |
| AFC | 1.03 (1.03, 1.04) | <0.0001 | 1.03 (1.03, 1.03) | <0.0001 | 0.98 (0.97, 0.99) | <0.0001 |
| COS protocols | ||||||
| GnRH agonist protocol | Ref. | Ref. | Ref. | |||
| GnRH antagonist protocol | 0.58 (0.55, 0.61) | <0.0001 | 0.49 (0.47, 0.52) | <0.0001 | 1.15 (1.04, 1.27) | 0.0084 |
| Gn dosage(IU) | 1.00 (1.00, 1.00) | <0.0001 | 1.00 (1.00, 1.00) | <0.0001 | 1.00 (1.00, 1.00) | <0.0001 |
| Gn duration(day) | 1.03 (1.02, 1.04) | <0.0001 | 1.03 (1.02, 1.03) | <0.0001 | 1.01 (0.99, 1.03) | 0.1999 |
| E2 level on trigger day(pg/ml) | 1.00 (1.00, 1.00) | <0.0001 | 1.00 (1.00, 1.00) | <0.0001 | 1.00 (1.00, 1.00) | 0.0268 |
| LH level on hCG trigger day(mIU/ml) | 0.96 (0.95, 0.98) | <0.0001 | 0.96 (0.95, 0.97) | <0.0001 | 1.01 (0.99, 1.03) | 0.4798 |
| P level on hCG trigger day(ng/ml) | 0.96 (0.95, 0.98) | <0.0001 | 1.04 (1.02, 1.06) | <0.0001 | 0.99 (0.96, 1.03) | 0.5807 |
| EMT on hCG trigger day (mm) | 1.07 (1.06, 1.08) | <0.0001 | 1.06 (1.06, 1.07) | <0.0001 | 0.95 (0.94, 0.97) | <0.0001 |
| No. of retrieved oocytes | 1.04 (1.03, 1.04) | <0.0001 | 1.02 (1.02, 1.03) | <0.0001 | 0.97 (0.97, 0.98) | <0.0001 |
| No. of embryos transferred | 1.46 (1.41, 1.52) | <0.0001 | 1.93(1.85, 2.01) | <0.0001 | 0.89 (0.83, 0.97) | 0.0044 |
| Embryo type | ||||||
| Embryos in cleavage stage | Ref. | Ref. | Ref. | |||
| Blastocyst | 1.37 (1.30, 1.44) | <0.0001 | 1.20 (1.15, 1.26) | <0.0001 | 1.04 (0.94, 1.14) | 0.3491 |
| others | 0.06 (0.03, 0.11) | <0.0001 | 0.06 (0.03, 0.13) | <0.0001 | 0.00 (0.00, inf.) | 0.9061 |
| Embryo quality | ||||||
| good | Ref. | Ref. | Ref. | |||
| Not good | 0.58 (0.56, 0.61) | <0.0001 | 0.56 (0.54, 0.59) | <0.0001 | 1.11 (1.01, 1.21) | 0.0234 |
| others | 0.37 (0.15, 0.94) | 0.0374 | 0.30 (0.10, 0.89) | 0.0306 | 0.00 (0.00, inf.) | 0.9311 |
BMI, body mass index; AMH, anti-Mullerian hormone; AFC, antral follicle counting; controlled COS, ovarian stimulation; GnRH, gonadotropin-releasing hormone; Gn, gonadotropin; E2, estradiol; LH, luteinizing hormone; P, progesterone; EMT, endometrium thickness.