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. 2022 Jan 24;12:748303. doi: 10.3389/fimmu.2021.748303

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Copyright © 2022 Francisco, Billod, Merino, Punzón, Gallego, Arranz, Martin-Santamaria and Fresno

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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General view of O. intermedium lipopolysaccharide (LPS) and (E) coli LPS docked in hTLR4/MD-2 dimer. (A) Full O. intermedium LPS (in purple) conformation with the core diving toward TLR4*–TLR4 interface. (B) E. coli LPS pose (in cyan) superimposed with O. intermedium LPS pose (in purple) in hTLR4/MD-2 dimer (hTLR4 and MD-2 are in gray, and hTLR4/MD-2* was omitted for clarity). The polar interactions established between (C) E. coli LPS and (D) O. intermedium LPS with TLR4* (brown), TLR4 (in orange), and MD-2 (in gray) residues are presented. (An asterisk distinguishes the second TLR4/MD-2 monomer).