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. 2022 Jan 24;10:819484. doi: 10.3389/fcell.2022.819484

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Copyright © 2022 Wu, Wei, Duan, Liu, Ou-Yang, Huang and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selection of hub methylation-driven genes. (A) Schematic workflow for the screening of methylation-driven genes in THCA. (B) GO and KEGG pathway analyses of 168 indicated methylation-driven genes. (C) MCODE algorithm identifying the major modules of 168 methylation-driven genes. (D) Protein-protein interaction network and K-means clustering model of hub genes. (E) Hub gene correlation at the transcriptional level. (F) Hub genes’ linkage score at the protein level.