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. 2022 Jan 24;10:819484. doi: 10.3389/fcell.2022.819484

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Copyright © 2022 Wu, Wei, Duan, Liu, Ou-Yang, Huang and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Validation of methylation levels and the expression of PLAU in THCA. Violin plots showing (A) the methylation levels and (D) mRNA levels of PLAU between normal and tumor tissues in THCA patients, Student’s t-test, ***p < 0.001. (B,C) Validation of the methylation levels of PLAU in THCA using data from the GEO database (GSE89961 and GSE97466), Student’s t-test, ***p < 0.001. (E) Comparison of the expression of PLAU between normal and tumor tissue in THCA patients using data from the GEO database (GSE33630, GSE35570 and GSE60542), Student’s t-test, ***p < 0.001. (F,G) Detection of the expression of PLAU in 12 pairs of matched cancerous and para-cancerous tissues of DTC via immunohistochemistry (IHC), Student’s t-test, ***p < 0.001. Kaplan-Meier plot for relapse-free survival (RFS) in THCA patients with different (H) methylation levels or (I) mRNA levels of PLAU.