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. 2022 Jan 24;11:773496. doi: 10.3389/fcimb.2021.773496

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Copyright © 2021 Broderick, Regtien, Ainsworth, Taylor and Pillarisetti

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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16S rRNA gene-based bacterial alpha-diversity in paired before and after treatment for bronchiectasis exacerbation in paediatric patients. After assessing data for normality using the Shapiro-Wilks test, significance was calculated by using a paired t-test for the Shannon diversity metric and Wilcoxon rank-sum test for the observed number of ASVs. Diversity was higher in sputum samples than nasal samples but diversity did not significantly change following antibiotic treatment in any sample type.