Table 2.
HR (95% CI) or β (95% CI) for Outcomes Across Groups of Neutrophil-to-Albumin Ratios
| Non-Adjusted | Adjust I | Adjust II | ||||
|---|---|---|---|---|---|---|
| Mortality | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value |
| 30-Day all-cause mortality | ||||||
| NPAR | 1.04 (1.03, 1.05) | <0.001 | 1.04 (1.03, 1.05) | <0.001 | 1.02 (1.01, 1.03) | <0.001 |
| Tertiles | ||||||
| <22.56 | 1.00 | 1.00 | 1.00 | |||
| 22.56–27.64 | 1.27 (1.01, 1.59) | 0.037 | 1.22 (0.97, 1.53) | 0.085 | 1.18 (0.93, 1.49) | 0.171 |
| >27.64 | 2.29 (1.87, 2.81) | <0.001 | 2.18 (1.78, 2.67) | <0.001 | 1.52 (1.22, 1.90) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| In-hospital all-cause mortality | ||||||
| NPAR | 1.02 (1.00, 1.03) | 0.004 | 1.01 (1.00, 1.02) | 0.017 | 1.00 (0.99, 1.02) | 0.416 |
| Tertiles | ||||||
| <22.56 | 1.00 | 1.00 | 1.00 | |||
| 22.56–27.64 | 1.01 (0.78, 1.30) | 0.968 | 0.96 (0.74, 1.24) | 0.752 | 0.99 (0.76, 1.29) | 0.962 |
| >27.64 | 1.37 (1.10, 1.72) | 0.006 | 1.31 (1.04, 1.64) | 0.020 | 1.09 (0.85, 1.40) | 0.483 |
| P for trend | 0.002 | 0.007 | 0.436 | |||
| 90-Day all-cause mortality | ||||||
| NPAR | 1.04 (1.03, 1.04) | <0.001 | 1.04 (1.03, 1.05) | <0.001 | 1.02 (1.01, 1.03) | <0.001 |
| Tertiles | ||||||
| <22.56 | 1.00 | 1.00 | 1.00 | |||
| 22.56–27.64 | 1.28 (1.07, 1.53) | 0.007 | 1.24 (1.03, 1.48) | 0.022 | 1.19 (0.99, 1.43) | 0.069 |
| >27.64 | 2.17 (1.84, 2.56) | <0.001 | 2.09 (1.77, 2.47) | <0.001 | 1.46 (1.22, 1.75) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| 365-Day all-cause mortality | ||||||
| NPAR | 1.03 (1.03, 1.04) | <0.001 | 1.04 (1.03, 1.04) | <0.001 | 1.02 (1.01, 1.03) | <0.001 |
| Tertiles | ||||||
| <22.56 | 1.00 | 1.00 | 1.00 | |||
| 22.56–27.64 | 1.24 (1.07, 1.43) | 0.004 | 1.20 (1.04, 1.39) | 0.012 | 1.14 (0.99, 1.33) | 0.075 |
| >27.64 | 2.01 (1.76, 2.30) | <0.001 | 1.97 (1.72, 2.26) | <0.001 | 1.43 (1.24, 1.66) | <0.001 |
| P for trend | <0.001 | <0.001 | <0.001 | |||
| Hospital LOS, day | β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value |
| NPAR | 0.19 (0.14, 0.24) | <0.001 | 0.19 (0.14, 0.24) | <0.001 | 0.07 (0.01, 0.12) | 0.017 |
| Tertiles | ||||||
| <22.56 | 0.00 | 0.00 | 0.00 | |||
| 22.56–27.64 | 0.74 (−0.24, 1.72) | 0.139 | 0.80 (−0.18, 1.77) | 0.109 | −0.23 (−1.18, 0.73) | 0.643 |
| >27.64 | 3.87 (2.89, 4.85) | <0.001 | 3.93 (2.95, 4.90) | <0.001 | 1.38 (0.35, 2.40) | 0.008 |
| P for trend | <0.001 | <0.001 | 0.006 | |||
Notes: Non-adjusted and Adjust I and II were derived from Cox proportional hazards regression models: Adjust I covariates were adjusted for age, gender and ethnicity; Adjust II covariates were adjusted for age, gender, ethnicity, anion gap, bicarbonate, APTT, INR, PT, serum urea nitrogen, RDW, heart rate, SBP, DBP, RR, temperature, SpO2, cardiac arrhythmias, hypertension, vasopressin use, mechanical ventilation, infected, SAPSII, APSIII. The data came from patients in MIMIC III database.
Abbreviations: NPAR, ratio of neutrophil to albumin; HR, hazard ratio; CI, confidence interval; OR, odds ratio; RRT, renal replacement treatment; APTT, activated partial thromboplastin time; INR, international normalized ratio; PT, prothrombin time; RDW, red blood cell distribution width; SBP, systolic blood pressure; DBP, diastolic blood pressure; RR, respiratory rate; SpO2, pulse oximetry-derived oxygen saturation; SAPSII, simple acute physiology score II; APSIII, acute physiology score III; LOS, length of stay.