Table 3.
Subgroup Analysis of the Association Between NPAR and 30-Day Mortality
| Variables | No. of Patients | HR | Lower Limit of 95% CI | Upper Limit of 95% CI | P for Interaction |
|---|---|---|---|---|---|
| Age, years | 0.942 | ||||
| <75 | 1471 | 1.04 | 1.02 | 1.05 | |
| ≥75 | 1471 | 1.04 | 1.03 | 1.05 | |
| Gender | 0.381 | ||||
| Male | 1511 | 1.04 | 1.03 | 1.06 | |
| Female | 1431 | 1.04 | 1.02 | 1.05 | |
| Ethnicity | 0.491 | ||||
| White | 2123 | 1.04 | 1.03 | 1.05 | |
| Black | 348 | 1.04 | 1.02 | 1.06 | |
| Other | 471 | 1.03 | 1.00 | 1.05 | |
| MAP, mmHg | 0.165 | ||||
| <74 | 1468 | 1.03 | 1.02 | 1.04 | |
| ≥74 | 1469 | 1.04 | 1.03 | 1.06 | |
| Heart rate, beats/minute | 0.233 | ||||
| <84 | 1468 | 1.05 | 1.04 | 1.07 | |
| ≥84 | 1469 | 1.03 | 1.02 | 1.04 | |
| RR, times/minute | 0.118 | ||||
| <20 | 1468 | 1.04 | 1.03 | 1.05 | |
| ≥20 | 1469 | 1.04 | 1.03 | 1.05 | |
| CHF | 0.632 | ||||
| Yes | 2842 | 1.04 | 1.03 | 1.05 | |
| No | 100 | 1.02 | 0.95 | 1.10 | |
| Valvular disease | 0.292 | ||||
| Yes | 686 | 1.05 | 1.03 | 1.08 | |
| No | 2256 | 1.04 | 1.03 | 1.05 | |
| Hypertension | 0.447 | ||||
| Yes | 1798 | 1.04 | 1.03 | 1.05 | |
| No | 1144 | 1.03 | 1.02 | 1.05 | |
| Renal failure | 0.558 | ||||
| Yes | 996 | 1.04 | 1.03 | 1.06 | |
| No | 1946 | 1.04 | 1.03 | 1.05 | |
| Serum creatinine, mg/dl | 0.768 | ||||
| ≤1.4 | 1455 | 1.04 | 1.03 | 1.05 | |
| ≥1.5 | 1487 | 1.04 | 1.03 | 1.05 | |
| Glucose, mg/dl | 0.761 | ||||
| ≤134 | 1458 | 1.03 | 1.02 | 1.05 | |
| ≥135 | 1482 | 1.05 | 1.03 | 1.06 | |
| Serum urea nitrogen, mg/dl | 0.815 | ||||
| ≤32 | 1454 | 1.04 | 1.03 | 1.05 | |
| ≥33 | 1488 | 1.04 | 1.02 | 1.05 | |
| RDW, fl | 0.636 | ||||
| ≤15.2 | 1421 | 1.04 | 1.02 | 1.06 | |
| ≥15.3 | 1518 | 1.03 | 1.02 | 1.04 | |
| Anion gap, mmol/l | 0.065 | ||||
| ≤15 | 1379 | 1.04 | 1.03 | 1.05 | |
| ≥16 | 1563 | 1.05 | 1.03 | 1.06 | |
| APTT, second | 0.756 | ||||
| ≤31 | 1421 | 1.04 | 1.02 | 1.06 | |
| >31 | 1428 | 1.04 | 1.03 | 1.05 | |
| INR | 0.114 | ||||
| ≤1.2 | 1147 | 1.04 | 1.02 | 1.06 | |
| ≥1.3 | 1699 | 1.03 | 1.02 | 1.04 | |
| PT, second | 0.103 | ||||
| ≤14.5 | 1416 | 1.03 | 1.01 | 1.05 | |
| ≥14.6 | 1430 | 1.04 | 1.03 | 1.05 | |
| SAPSII | 0.526 | ||||
| ≤40 | 1464 | 1.04 | 1.02 | 1.06 | |
| ≥41 | 1478 | 1.03 | 1.02 | 1.04 | |
| APSIII | 0.614 | ||||
| ≤50 | 1419 | 1.03 | 1.01 | 1.05 | |
| ≥51 | 1523 | 1.03 | 1.02 | 1.04 |
Notes: HR (95% CI) were derived from Cox proportional hazards regression models. The data came from patients in MIMIC III database.
Abbreviations: NPAR, ratio of neutrophil to albumin; HR, hazard ratio; CI, confidence interval; MAP, mean arterial pressure; RR, respiratory rate; CHF, congestive heart failure; RDW, red blood cell distribution width; APTT, activated partial thromboplastin time; INR, international normalized ratio; PT, prothrombin time; SAPSII, simple acute physiology score II; APSIII, acute physiology score III.