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. 2022 Jan 24;12:797390. doi: 10.3389/fimmu.2021.797390

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Copyright © 2022 Nguyen, Schioppa, Tiberio, Facchinetti, Villetti, Civelli, Del Prete, Sozio, Gaudenzi, Passari, Barbazza, Sozzani, Salvi and Bosisio

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Tanimilast on moDC phenotypic maturation induced by SCV2-RNA. (A, B) moDCs were pre-treated or not (-) with either Tanimilast (Tan) or β-methasone (β-meth) (both at 10^-7M) for 1 hour and subsequently stimulated or not with SCV2-RNA for 24 hours. The surface expression of activating markers CD83, CD86, CCR7 (A) and of antigen presenting molecules MHC-I, MHC-II (B) were evaluated by FACS analysis. Data are expressed as representative cytofluorimetric profiles (left panels),as the mean ± SEM (n=3-4) of the Median Fluorescence Intensity (MFI) (center panels) and of the percentage of positive cells (right panels). ^#P < 0.05 versus (-) and *P < 0.05 versus SCV2-RNA by one-way ANOVA with Dunnett’s post-hoc test.