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. 2022 Jan 8;298(2):101572. doi: 10.1016/j.jbc.2022.101572

Figure 4.

Figure 4

The enzyme activities involved in cholesterol biosynthesis were not significantly altered in livers of the diabetic mice treated with C22:1 or HRO.A–C, liver cytosolic AcAc-CoA thiolase (A), cytosolic HMG-CoA synthase (B), and microsomal HMG-CoA reductase (C) activities were not significantly affected in the STZ-induced diabetic mice after the treatment with OO, HRO, C22:1 or TDYA. D, liver cytosolic HMG-CoA lyase activity was elevated in the diabetic mice compared to the normal control, whereas there was no alteration in the diabetic mice treated with C22:1, OO, HRO, or TDYA. E, liver microsomal squalene synthase activity was not statistically different among all the groups. Mean ± SEM, n = 8, ∗p < 0.05 by t test between paired conditions. AcAc-CoA, acetoacetyl-CoA; HRO, high erucic acid rapeseed oil; OO, olive oil; STZ, streptozotocin; TDYA, 10,12-tricosadiynoic acid.