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. 2022 Jan 24;11:782515. doi: 10.3389/fonc.2021.782515

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Copyright © 2022 Chen, Kuai, Wang, Zhu, Wang, Liu, Cheng and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Class activation maps for morphological features. (A) Macrograph (top), input image (second from top), CAM (third from top), and corresponding sketch maps of predominant morphological feature (bottom) for EMT subtypes (from left to right: Epi and Mes). Epi region is a granular eosinophilic cytoplasm area with a looser arrangement, big cell gap, nucleoli absent. Mes region contained mostly tumor cells with empty cytoplasm and mixed with immune cells. (B) GSEA plot of abnormality of the mitochondrion in Epi cluster (left) and positive correlation between AI score and immune score (estimated by the ESTIMATE algorithm).