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. 2022 Jan 24;9:834171. doi: 10.3389/fchem.2021.834171

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Copyright © 2022 Zhao, Zhang, Wu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic description of the synthesis process of HA conjugated, ICG loading of MIL-100(Fe) nanomaterial. (B) TEM images of the MOF@HA@ICG NPs. (C) FL images (I) and T2-weighted MR images (II) of cells treated with MOF@HA@ICG solutions. (D) FL images of MCF-7 tumor-bearing mice injected with free ICG, MOF@ICG, or MOF@HA@ICG solutions (each with 170 μg/ml of ICG; the tumors are highlighted by red circles). (E) In vitro FL images of organs (heart, liver, kidney, spleen, and lung) and tumors. (F) In vivo PA images and T2-weighted MR images with MOF@HA@ICG treatment. The tumors are highlighted by red circles. Source: (Li et al., 2015).