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(A) The schematic illustration of the self-assembly of ZIF-90/protein and ATP-triggered protein release from ZIF-90 inside cells. (B) Selectivity of ATP triggered protein release from ZIF-90/GFP. (C) Cellular uptake efficiency of ZIF-90/GFP by HeLa cells. (D) The delivery of ZIF-90/Cas9 efficiently inhibits GFP expression of HeLa-GFP cells. HeLa-GFP cells were treated with ZIF-90/Cas9 nanoparticles (120 nM Cas9) alone with 60 nM sgRNA. Source: (Yang B et al., 2019).
