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. 2022 Feb 5;399(10324):541–553. doi: 10.1016/S0140-6736(21)02175-9

Figure 1.

Figure 1

Trial profile

*88 patients received trametinib following disease progression. †One patient randomly assigned to the standard-of-care group received trametinib instead and was included in the safety analysis for the trametinib group.