FIGURE 7.
TAS‐116 reduces tumor volume in SCID mice. HuT‐102 or Su9T01 cells (5 × 106 cells/mouse) were injected subcutaneously into SCID mice. When the tumor volume reached approximately 100 mm3, mice were divided into three groups based on treatment (control, 10 mg/kg TAS‐116, or 14 mg/kg TAS‐116). Mice were given the treatment orally for 28 d from the day of grouping, and time‐course changes in tumor volume were monitored on the indicated days. Data are expressed as the mean ± SD of five (HuT‐102) or four (Su9T01) mice. *P < .05, **P < .01 (analyzed using ANOVA followed by Dunnett’s test). BW, body weight