TABLE 1.
Top 10 downregulated pathways according to the Kyoto Encyclopedia of Genes and Genomes and genes common in three primary adult T‐cell leukemia/lymphoma cells
| Hepatitis B | Toll‐like receptor signaling pathway | ||
| EGR2 | Early growth response 2 | CCL3L3 | Chemokine (C‐C motif) ligand 3‐like 3 |
| FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit | TNF | Tumor necrosis factor |
| TNF | Tumor necrosis factor | CCL3 | Chemokine (C‐C motif) ligand 3 |
| STAT1 | Signal transducer and activator of transcription 1 | CCL4L2 | Chemokine (C‐C motif) ligand 4‐like 2 |
| E2F1 | E2F transcription factor 1 | FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit |
| MYC | MYC proto‐oncogene, bHLH transcription factor | STAT1 | Signal transducer and activator of transcription 1 |
| E2F2 | E2F transcription factor 2 | ||
| Chemokine signaling | |||
| HTLV‐1 infection | CCL2 | Chemokine (C‐C motif) ligand 2 | |
| EGR1 | Early growth response 1 | CCL3L3 | Chemokine (C‐C motif) ligand 3‐like 3 |
| EGR2 | Early growth response 2 | CCL3 | Chemokine (C‐C motif) ligand 3 |
| FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit | CCL4L2 | Chemokine (C‐C motif) ligand 4‐like 2 |
| TNF | Tumor necrosis factor | CXCR3 | Chemokine (C‐X‐C motif) receptor 3 |
| E2F1 | E2F transcription factor 1 | NCF1 | Neutrophil cytosolic factor 1 |
| MYC | MYC proto‐oncogene, bHLH transcription factor | ||
| LTA | Lymphotoxin α | Pathways in cancer | |
| E2F2 | E2F transcription factor 2 | FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit |
| STAT1 | Signal transducer and activator of transcription 1 | ||
| T‐cell receptor signaling pathway | E2F1 | E2F transcription factor 1 | |
| FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit | MYC | MYC proto‐oncogene, bHLH transcription factor |
| TNF | Tumor necrosis factor | E2F2 | E2F transcription factor 2 |
| PTPN6 | Protein tyrosine phosphatase, non‐receptor type 6 | NFKBIA | NF‐κB inhibitor α |
| NFKBIA | NF‐κB inhibitor α | ARNT2 | Aryl‐hydrocarbon receptor nuclear translocator 2 |
| CDC42 | Cell division cycle 42 | ||
| Cytokine‐cytokine receptor interaction | |||
| CCL2 | Chemokine (C‐C motif) ligand 2 | MAPK signaling pathway | |
| CCL3L3 | Chemokine (C‐C motif) ligand 3‐like 3 | FOS | Fos proto‐oncogene, AP‐1 transcription factor subunit |
| CCL3 | Chemokine (C‐C motif) ligand 3 | TNF | Tumor necrosis factor |
| TNF | Tumor necrosis factor | DUSP6 | Dual specificity phosphatase 6 |
| CCL4L2 | Chemokine (C‐C motif) ligand 4‐like 2 | MYC | MYC proto‐oncogene, bHLH transcription factor |
| CXCR3 | Chemokine (C‐X‐C motif) receptor 3 | CD14 | CD14 molecule, transcript variant 3 |
| DUSP4 | Dual specificity phosphatase 4 | ||
| Cell cycle | |||
| CDC45 | Cell division cycle 45 | ||
| E2F1 | E2F transcription factor 1 | ||
| MYC | MYC proto‐oncogene, bHLH transcription factor | ||
| E2F2 | E2F transcription factor 2 | ||
Abbreviations: AP‐1, activating protein‐1; HTLV‐1, human T‐cell leukemia virus type 1.