TABLE 1.
Summary of target proteins for cancer‐associated alterations in biomolecular condensates
| Protein | Cancer type | Cellular process | Reference |
|---|---|---|---|
| FET fusion | Ewing sarcoma | Transcription | 40, 57, 58 |
| NUP98 fusion | Pediatric AML | Transcription | 59, 60 |
| YAP, TAZ | Breast cancer | Transcription | 61, 62 |
| AKAP95 | Breast cancer | Transcription, RNA splicing | 63 |
| YTHDC1 | AML | RNA modification | 64 |
| ASXL1 | Myeloid neoplasm | Epigenetic regulation | 65 |
| EML4‐ALK | Lung cancer | Cellular signaling | 69 |
| CCDC6‐RET | Lung cancer | Cellular signaling | 69 |
| DnaJB1‐PKAcat | Fibrolamellar hepatocellular carcinoma | Cellular signaling | 70 |
| DACT1 | Breast cancer, prostate cancer | Cellular signaling | 71 |
| SPOP | Solid tumors (prostate cancer) | Protein homeostasis | 72 |
| KEAP1, NRF2 | Multiple cancer types (lung cancer) | Protein homeostasis, metabolism | 73 |
| KRAS | Multiple cancer types (pancreatic cancer) | Stress granule | 74 |
| YB‐1 | Sarcoma | Stress granule | 75 |
| DDX3X | Multiple cancer types (medulloblastoma) | Stress granule | 76 |