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. 2021 Dec 22;113(2):634–647. doi: 10.1111/cas.15238

FIGURE 4.

FIGURE 4

miR‐139‐3p can reverse the carcinogenic effects of hsa_circ_0003410. A, RNA pull‐down verifies the interaction between hsa_circ_0003410 and miR‐139‐3p. B, Transfection efficiency of miR‐139‐3p mimics or inhibitor. C, miR‐139‐3p inhibited HCC cell viability. D‐G, miR‐139‐3p could inhibit cell proliferation and migration ability and reverse the oncogenic effect of hsa_circ_0003410. H, miR‐139‐3p inhibited CCL5 expression as shown by concentration gradient experiment. I, J, RNA‐FISH of hsa_circ_0003410 and CCL5 in HCC cells. K, CCL5 protein expression detected by western blot in HCC cells. L, Secreted CCL5 protein level detected by ELISA