Effective reproduction numbers RtEmpirical and RtModel-based in Qatar. A) Trend in RtEmpirical and RtModel-based, April 1, 2020 to August 18, 2021, and association with major events, response landmarks, and introduction and expansion of the Alpha (B.1.1.7) and Beta (B.1.135) variants. B) Trend in RtEmpirical for only the Alpha variant cases, February 1, 2021 to April 1, 2021. RtEmpirical was estimated using the Robert Koch Institute method [23] applied to symptomatic case series data. The dashed green line represents the threshold of R0 = 1.