FIGURE 3.

Methyltransferase‐like 14 (METTL14) suppresses renal cell carcinoma tumor growth and metastasis in vivo. A, Subcutaneous xenograft models were established with METTL14 overexpressing (OE‐METTL14) or control (OE‐NC) 769‐P cells (n = 6). B, C, Growth curve (B) and weight (C) of OE‐METTL14 tumors compared to control group (OE‐NC). D, Immunohistochemical assays showing METTL14 and Ki‐67 expression in each group. Scale bar, 200 μm. E, F, Representative metastatic lung nodules in each group and quantification of the number of metastatic nodules. Magnification, 400×. Error bars represent mean ± SD. Mann‐Whitney U test (C, F) and two‐way ANOVA test (B) were used. *P < .05, **P < .01, ***P < .001