FIGURE 6.

PDRG1 silencing inhibited the growth of primary glioma. Luciferase‐labeled U118 cells were used to establish the intracranial glioma model and tumor growth was recorded in vivo using bioluminescent imaging. Representative bioluminescent images (A) and the quantification (B) of the U118 tumor‐bearing mice on days 7, 14, and 21. The data are shown as mean ± SD (n = 8). (C) Growth of glioma was detected by HE staining after U118 tumor‐bearing mice were sacrificed. Luciferase‐labeled U118 cells were used to establish the subcutaneous glioma model and tumor growth was recorded in vivo using bioluminescent imaging. Representative bioluminescent images (D) and the quantification (E) of the tumor‐bearing mice on days 7, 14, and 21. The data are shown as mean ± SD (n = 6). F, Representative IHC images of the intracranial glioma tissue from U118 tumor‐bearing mice stained by Ki67 and PDRG1. (G) Correlation analysis of PDRG1 and Ki67 expression in 96 glioma clinical specimens. Scale bars, 50 μm. Error bars, SD. H, The growth of the glioma from U87 tumor‐bearing mice was evaluated by HE staining method. I, Representative images of the subcutaneous glioma tissue from U87 tumor‐bearing mice. (n = 6). J, Tumor growth curve of subcutaneous glioma in U87 tumor‐bearing mice