Table 3.
Comparison Between Patients With and Without Severe AEs
| Characteristics | Patients With Severe AEs (n = 60) | Patients Without Severe AEs (n = 239) | p Value |
|---|---|---|---|
| Age (y) | 0.21 | ||
| Median (range) | 68 (46–80) | 68 (31–84) | |
| Sex, n (%) | 0.88 | ||
| Male | 45 (75) | 177 (74) | |
| Smoking status, n (%) | 0.85a | ||
| Current | 24 (40) | 92 (38) | |
| Former | 27 (45) | 107 (45) | |
| Never | 9 (15) | 40 (17) | |
| ECOG PS, n (%) | 0.17a | ||
| 0 | 12 (20) | 83 (35) | |
| 1 | 43 (72) | 147 (61) | |
| 2 | 3 (5) | 8 (3) | |
| 3 | 2 (3) | 1 (1) | |
| Histology, n (%) | 0.15 | ||
| Adenocarcinoma | 53 (88) | 225 (94) | |
| Others | 7 (12) | 14 (6) | |
| Stage, n (%) | |||
| 3 | 2 (3) | 9 (4) | |
| 4 | 51 (85) | 177 (74) | |
| Recurrence after surgery | 7 (12) | 39 (16) | |
| Recurrence after radiotherapy | 0 (0) | 14 (6) | |
| PD-L1 TPS, n (%) | 0.86a | ||
| ≥50% | 13 (22) | 52 (22) | |
| 1%–49% | 22 (37) | 82 (34) | |
| <1% | 19 (32) | 93 (39) | |
| Not investigated | 6 (10) | 12 (5) | |
| Pre-existing interstitial lung disease, n (%) | 3 (5) | 10 (4) | 0.73 |
| Emphysema, n (%) | 25 (42) | 89 (37) | 0.53 |
| Previous thoracic radiotherapy, n (%) | 6 (10) | 27 (11) | 1.00 |
AE, adverse event; ECOG PS, Eastern Cooperative Oncology Group performance status; PD-L1, programmed death-ligand 1; TPS, tumor proportion score.
a
Smokers versus never-smokers, ECOG PS 0 to 1 versus ECOG PS 2 to 3, and greater than or equal to 50% versus less than 50% PD-L1 expression.