Fig. 3.

Knockout of CNTF blocks chronic stress-induced reduction of sucrose preference only in female mice. Sucrose preference was performed at 4 h after control handling or CUS to evaluate behavioral anhedonia. A) After 4 weeks of CUS, CNTF+/+, but not CNTF−/−, females had reduced sucrose preference compared to their own genotype controls. N = 10 mice/group. B) In male mice, CUS reduced sucrose preference in CNTF+/+ and CNTF−/− mice without genotype difference. N = 13,11,10,10 mice, *, p < 0.05, **p < 0.01 (Two-way ANOVA followed by Newman-keuls multiple comparisons).