Fig. 4.

CNTF−/− female, but not male, mice have a reduced restraint-induced neuroendocrine response following CUS. Plasma levels of corticosterone were measured at 24 h after control handling or CUS, with or without a subsequent 10 min of restraint challenge. A) In female mice, basal levels of corticosterone were not affected by CUS or genotype. Restraint challenge increased plasma corticosterone in CNTF+/+, but not CNTF−/−, females. B) In males, restraint challenge increased plasma corticosterone in both CNTF+/+ and CNTF−/− mice without genotype difference. N = 5,5,10,8,6,12 female mice and 6,6,7,7,12,9 male mice, *p < 0.05, **p < 0.01, ****p < 0.0001 (Two-way ANOVA followed by Newman-Keuls multiple comparisons).