Fig. 5.

CNTF knockout does not affect chronic stress-induced anxiety-like behavior in both sexes. Elevated T-maze and open field tests were performed at 24 and 48 h after 4 weeks of control handling or CUS. A) In the elevated T maze test, CUS increased latencies to enter the open arm in both sexes and genotypes, without genotype difference. B) CUS reduced latency to escape the open arm in female CNTF+/+ mice. N = 11, 11, 7, 11 females and 11, 9, 9, 8 males, *p < 0.05, **p < 0.01 (Two-way ANOVA followed by Newman-Keuls multiple comparisons). In the open field test, CUS increased time spent in the center area (C) of the open arena and reduced time spent in the peripheral area (D). N = 10, 10, 10, 10 females and 13, 11, 10, 10 males, *p < 0.05, **p < 0.01, ***p < 0.001 (Two-way ANOVA followed by Newman-Keuls multiple comparisons).