Figure 3.

AAV9 and AAV-F robustly transduce DRG neurons after intrathecal delivery to NHPs. (a) Anti-GFP immunohistochemistry was performed on DRG sections at three levels of the spinal cord. DAB brown staining indicates specific GFP detection. Scale bars = 300 μm. (b) Percentage of DRG positive for GFP in thoracic and lumbar regions. (c) Mean staining intensity of transduced DRG in thoracic and lumbar regions. Mean ± standard deviation are shown. Individual cells are shown as black data points. DAB, 3,3′-diaminobenzidine; DRG, dorsal root ganglion.