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. 2022 Feb 5;50(3):280–293. doi: 10.1177/01926233211072767

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© The Author(s) 2022

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Figure 5. — Histopathologic features of SARS-CoV-2 infection in hamster lungs at 3 dpi. (A) and (B) Broncho-interstitial pneumonia at 3 dpi, H&E stained. The interstitium is expanded with inflammatory cell infiltrates and fluid exudate (A). The alveolar and bronchiolar epithelium is multifocally necrotic (black arrows), and the bronchiolar lumen is filled with cellular debris (B). (C) to (E) Bronchiolar and alveolar epithelial cells (pneumocytes) show multifocal strong positivity for N by IHC (C), for viral RNA by RNAscope ISH using probes that target the positive-sense viral RNA (D), and the negative-sense genomic viral RNA (E); arrows point to infected cells containing the rarer negative-sense genomic viral RNA (E). dpi, days post-infection; H&E, hematoxylin and eosin; IHC, immunohistochemistry; ISH, in situ hybridization; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.