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. 2022 Feb 5;50(3):280–293. doi: 10.1177/01926233211072767

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Histopathologic features of SARS-CoV-2 infection in hamster lungs at 7 dpi. (A) to (C) Histopathological changes in the lungs at 7 dpi, H&E stained. Marked increases in lung cellularity caused by proliferation of bronchiolar and alveolar type II pneumocytes and perivascular edema and fibrosis (asterisk) (A). High magnification showing (B) hyperplastic bronchiolar epithelium and adjacent hypercellular lung parenchyma with syncytia (white arrowheads). High magnification showing (C) karyomegalic cells with suspected intracytoplasmic inclusion (black arrows and inset). (D) Black arrows and inset showing hyaline membrane lining alveolar surface. (E) Alveolar epithelium (pneumocytes) shows positivity for N by IHC. dpi, days post-infection; H&E, hematoxylin and eosin; IHC, immunohistochemistry; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.