Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Compounds 13 and 25, but not 61 and 62, potently induced AKT degradation in BT474 cells. BT474 cells were treated with 13 (A, C), 25 (B, D), 61 (E), or 62 (F) at indicated concentrations for 24 h. (G) Effects of CRBN-recruiting AKT degraders 25 and INY-03–041 on AKT degradation and downstream signaling inhibition in BT474 cells treated with the test compound at indicated concentrations.
