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. Author manuscript; available in PMC: 2022 Dec 23.
Published in final edited form as: J Med Chem. 2021 Dec 2;64(24):18054–18081. doi: 10.1021/acs.jmedchem.1c01476

Figure 14.

Figure 14.

AKT degraders 13 and 25 were bioavailable in mouse PK studies. Plasma concentrations of 13 (A) and 25 (B) following a single 50 mg/kg IP injection over 8 h in male Swiss albino mice. Experiments were carried out in biological triplicates, with points representing mean concentrations ± SEM.