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Schematic design of GDC-0068-based AKT putative degraders. (A) The crystal structure of AKT1 in complex with GDC-0068 (PDB: 4EKL) indicates that the isopropyl group is solvent-exposed. (B) Key hydrogen bonding interactions are indicated by yellow dotted lines. (C) Design of precursors for AKT degraders.
