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Effects of GSK690693-based AKT degraders on degrading AKT and inhibiting downstream signaling. PC3 cells were treated with GSK690693 or indicated compounds at 1 μM for 24 h. The cell lysates were analyzed by western blotting to examine the protein levels of T-AKT, P-AKT (S473), P-PRAS40 (T246), and P-S6 (S240/244). β-Actin was used as the loading control.
