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. Author manuscript; available in PMC: 2022 Dec 23.
Published in final edited form as: J Med Chem. 2021 Dec 2;64(24):18054–18081. doi: 10.1021/acs.jmedchem.1c01476

Figure 9.

Figure 9.

GDC-0068, 13, 61, 25, and 62 bind AKT1 (A), AKT2 (B), and AKT3 (C) with high affinities. The Kd determinations were performed in a competitive binding assay in duplicate. Error bars represent ± SEM from duplicated experiments.