Table 1.
Demographic, clinical, and demographically corrected cognitive scores by the study cohort
| Variable | NACC | ADNI | Mann-Whitney U | p value | ||
|---|---|---|---|---|---|---|
| Mdn | IQR | Mdn | IQR | |||
| Age | 73.00 | 11.00 | 72.10 | 10.83 | 49,563.00 | 0.54 |
| Education | 16.00 | 4.00 | 16.00 | 2.00 | 48,358.50 | 0.27 |
| Montreal Cognitive Assessment (raw score) | 22.00 | 5.00 | 24.00 | 3.00 | 41,345.00 | 0.00* |
| Functional Activities Questionnaire total score | 1.00 | 4.00 | 1.00 | 5.00 | 48,516.00 | 0.95 |
| Geriatric Depression Score | 1.00 | 3.00 | 1.00 | 3.00 | 49,358.50 | 0.53 |
| Naming | −0.43 | 1.72 | 0.09 | 1.47 | 41,338.00 | 0.00* |
| Animal fluency | −0.98 | 1.20 | −0.63 | 1.12 | 38,884.00 | 0.00* |
| Trailmaking A | −0.39 | 1.61 | −0.35 | 1.55 | 50,329.50 | 0.80 |
| Trailmaking B | −0.59 | 1.74 | −0.23 | 1.56 | 40,982.50 | 0.00* |
| Immediate story recall | −0.91 | 1.44 | −0.91 | 1.14 | 50,492.00 | 0.85 |
| Delayed story recall | −0.95 | 1.51 | −1.01 | 1.03 | 49,787.50 | 0.66 |
NACC, National Alzheimer’s Coordinating Center; ADNI, Alzheimer’s Disease Neuroimaging Initiative; Mdn, median; IQR, interquartile range.
*
Significant after false discovery rate analysis; all cognitive test scores except for the MoCA are presented in terms of demographically adjusted normative data.