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. 2022 Jan 24;12:807628. doi: 10.3389/fgene.2021.807628

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Copyright © 2022 Liu, Feng, Zeng, He, Gong and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KIF11 can restore the inhibitory impact of miRNA-30a-5p on cell proliferation, migration, and invasion of LUAD. (A) Effect of KIF11 expression in A549 and H1975 cells. (B) The impact of simultaneously overexpressing miRNA-30a-5p and KIF11 on the viability of LUAD cells. (C) The impact of simultaneously overexpressing miRNA-30a-5p and KIF11 on colony formation ability of LUAD cells. (D) The influence of simultaneously overexpressing miRNA-30a-5p and KIF11 on migratory ability of LUAD cells (40 ×). (E) The effect of simultaneously forced expression of miRNA-30a-5p and KIF11 on invasive property of LUAD cells (100 ×). * represents p < 0.05 when NC-mimic + oe-NC group was compared to miR-30a-5p-mimic + oe-NC group and when miR-30a-5p-mimic + oe-NC was compared to miR-30a-5p-mimic + oe-KIF11 group. All assays were repeated three times in triplicate.