Table 3.
Formalin | Complete Freund’s Adjuvant | Carrageenan | Osteoarthritis | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Drug Class | K | N | Effect size | 95 % CI | K | N | Effect size | 95 % CI | K | N | Effect size | 95 % CI | K | N | Effect size | 95 % CI |
Anandamide transport inhibitor | 10 | 64 | 1.97 | 0.608 - 3.342 | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT |
CB1 receptor agonist | 59 | 496 | 1.12 | 0.731 - 1.502 | 21 | 144 | 0.74 | 0.378 - 1.107 | ns | ns | ns | ns | 3 | 16 | 1.22 | 0.378 - 1.107 |
CB1 receptor inverse agonist | 1 | 7 | 1.71 | 0.427 - 3.002 | NT | NT | NT | NT | 5 | 30 | 0.44 | 0.055 - 0.822 | NT | NT | NT | NT |
CB1 receptor PAM | NT | NT | NT | NT | NT | NT | NT | NT | 1 | 8 | 2.45 | 1.067 - 3.837 | NT | NT | NT | NT |
CB2 receptor agonist | 33 | 265 | 0.81 | 0.316 - 1.307 | 44 | 338 | 1.10 | 0.829 - 1.366 | 10 | 74 | 1.39 | 0.885 - 1.896 | 24 | 173 | 1.42 | 0.829 - 1.366 |
CB2 receptor inverse agonist | 3 | 22 | 1.05 | 0.653 - 1.444 | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT | NT |
CBD | 2 | 16 | 1.86 | 1.548 - 2.169 | 5 | 20 | 1.59 | 0.71 - 2.469 | ns | ns | ns | ns | ns | ns | ns | ns |
Dual FAAH/MAGL inhibitor | NT | NT | NT | NT | ns | ns | ns | ns | 4 | 36 | 1.42 | 0.25 - 2.6 | NT | NT | NT | NT |
FAAH inhibitor | 23 | 184 | 1.50 | 1.134 - 1.862 | 24 | 144 | 1.24 | 0.702 - 1.781 | ns | ns | ns | ns | ns | ns | ns | ns |
FABP inhibitor | ns | ns | ns | ns | 15 | 98 | 0.78 | 0.194 - 1.373 | 6 | 36 | 1.42 | 0.947 - 1.895 | NT | NT | NT | NT |
Monoacylglycerol lipase inhibitor | 8 | 69 | 2.28 | 1.382 - 3.175 | ns | ns | ns | ns | 8 | 60 | 2.67 | 0.967 - 4.378 | ns | ns | ns | ns |
NAAA inhibitor | NT | NT | NT | NT | 3 | 30 | 1.63 | 1.235 - 2.025 | 12 | 72 | 1.91 | 0.923 - 2.897 | NT | NT | NT | NT |
Non-selective cannabinoid receptor agonist | 38 | 253 | 1.56 | 1.019 - 2.11 | ns | ns | ns | ns | 45 | 311 | 0.74 | 0.202 - 1.268 | ns | ns | ns | ns |
PPAR-alpha agonist | 21 | 143 | 1.73 | 0.701 - 2.761 | 2 | 16 | 2.53 | 0.851 - 4.205 | 26 | 173 | 3.26 | 1.51 - 5.006 | 9 | 75 | 0.98 | 0.851 - 4.205 |
THC | 20 | 118 | 1.16 | 0.679 - 1.643 | 16 | 109 | 2.34 | 1.687 - 2.986 | 5 | 37 | 2.13 | 0.138 - 4.12 | NT | NT | NT | NT |
K denotes the number of comparisons and N denotes the number of animals within each sub-group. All entries with an effect size value were statistically significant. NT, not tested, ns, not significant.