Table 2.

Outcomes of Systemic DFO Treatment in Animal Models of AD at Various Doses and Dosing Intervals

source	animal model	formulation	dose administered	outcome
Savory etal.59	New Zealand white rabbits receiving intracisternal Injections of Al	IM DFO	given 2 days prior to sacrifice at 4, 6, or 8 days	DFO treatment reversed Al-induced neurofibrillary degeneration
Esparza etal.60	female AβPP transgenic mice orally exposed to Al	SC injections	0.20 mmol/kg/d twice per week for six months	DFO treatment does not appear to mitigate pro-oxidative events