TABLE 3.
Regulatory effects of LGR4 gene on metabolic diseases.
| Pathway | Effect | References |
|---|---|---|
| LGR4-cAMP/PKA | LGR4 KO mice had aldosterone resistance | Wang et al. (2012) |
| Rspo1/Rspo3/LGR4 | Injection of Rspo1 or Rspo3 inhibited food intake | Li et al. (2014) |
| R-spondin1-LGR4-Pomc | LGR4 KO mice didn’t exhibit a suppressed appetite | Otsuka et al. (2019) |
| LGR4-Ampk/Sirt1/Pgc1α pathway | LGR4 ablation enhanced fuel shift | Sun et al. (2015) |
| Rspo1/Rspo3-LGR4-AMPKα-SREBP2 pathway | Rspo1/Rspo3-LGR4 signaling suppresses cholesterol synthesis | Liu et al. (2020b) |