TABLE 4.

Increased impacts of LGR4 gene on oxidative stress response.

Pathway	Effect	References
Rspo1-LGR4-Wnt3a/β-catenin-NF-κB-p65	LGR4 protected hepatocytes from injury	Liu et al. (2018); Li et al. (2019b)
LGR4-ERK signaling-oxidative stress	LGR4 protected cardiomyocyte against I/R	Chen et al. (2021a)
RSPO2-LGR4-PI3K-AKT-Enos/Wnt-β-catenin	LGR4 silencing promoted lymphangiogenesis	Singla et al. (2020)
LGR4-CREB-mediated c-Fos/Fosl1/Fosb/AP-1	LGR4 knockout infarcts had reduced inflammatory	Huang et al. (2020)
Rspo1-LGR4-mTOR-autophagy	Exogenous Rspo1-LGR4 alleviated radiation-induced bone loss	Chen et al. (2021b)