TABLE 5.
The gene of LGR4 involving in the process of multiple tumors.
| Cancer subtypes | Pathway | Effect | References |
|---|---|---|---|
| Skin carcinoma | LGR4-MEK1/ERK1/2/AP-1 and Wnt/β-catenin pathways | LGR4 was crucial for skin carcinogenesis | Xu et al. (2016) |
| Glioma | LGR4-Wnt/β-catenin | LGR4 overexpression promoted cell proliferation | Yu et al. (2013) |
| Uveal melanoma | MiR-34a-LGR4-MMP2 | Knockdown of LGR4 attenuated the aggressiveness | Hou et al. (2019) |
| Tongue carcinoma | Rspo2-LGR4-Wnt/β-catenin | Elevated LGR4 promoted growth | Zhang et al. (2019) |
| Thyroid carcinomas | R-spondin2-LGR4-p-ERK-p-LRP6–p-GSK3β-β-catenin | Elevated expression of LGR4 promoted proliferation and migration | Kang et al. (2017) |
| Lung cancer | RSPO3-LGR4- IQGAP1, MiR-449b-LGR4 | Knockdown of LGR4 decreased tumor growth | Gong et al. (2015); Yang et al. (2018) |
| Colon cancer | p27Kip1- LGR4, CircLGR4-LGR4-Wnt/β-catenin, LGR4-GSK3β-PI3K/Akt-MAPK-ERK1/2-catenin/TCF-Cyclin D1/c-Myc, LncGata6-NURF-Ehf-LGR4/5-Wnt | LGR4 expression was associated with colorectal tumorigenesis | Gao et al. (2006); Wu et al. (2013); Zhu et al. (2018); Zhi et al. (2019) |
| Acute myeloid leukemia | RSPO3-LGR4-HOXA9 | RSPO3-LGR4 interaction promoted proliferation | Salik et al. (2020) |
| Multiple myeloma | IL-6/STAT3-LGR4/R-spondin- Wnt/β-catenin | LGR4 expression was driven by IL-6/STAT3 signaling and allowed MM cells to hijack R-spondins | van Andel et al. (2017) |
| Osteosarcoma | Stat3-LGR4 | Overexpression of Stat3 promoted LGR4 expression | Liu et al. (2013a) |
| Breast cancer | LGR4- Wnt/β-catenin signaling, LGR4-EGFR signaling | LGR4 down-regulation decreased tumor growth and lung metastasis | Zhu et al. (2013); Yue et al. (2018); Yue et al. (2021) |
| Prostate cancer | LGR4-EMT, LGR4-Jmjd2a/AR signaling-PSA, MiR-137-LGR4-EGFR/ERK, LGR4-AR/CREB1 expression, LGR4-PI3K/Akt/mTOR | LGR4 knockdown impaired cell migration | Liang et al. (2015); Zhang et al. (2016); Luo et al. (2017); Zhang et al. (2020); Liang et al. (2021) |
| Ovarian cancer | WNT7B/FZD5-LGR4/ELF3 axis | LGR4 overexpression enhanced tumorisphere formation capacity | Wang et al. (2020c) |
| Cervical cancer | XIST/LGR4, XIST/miR-23a-3p/LGR4 | — | Berti et al. (2021) |