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. 2022 Jan 24;10:817112. doi: 10.3389/fcell.2022.817112

FIGURE 2.

FIGURE 2

Writers, erasers and readers mediates downstream targets to regulate PCD in a m6A-dependent manner. METTL3 promotes ferroptosis and apoptosis, and inhibits necroptosis, via regulating downstream targets. According to the different functions of downstream targets, METTL3 can inhibit or promote pyroptosis and autophagy. METTL14 regulates downstream targets to promote ferroptosis, pyroptosis, and apoptosis. FTO and ALKBH5 mediate downstream targets to promote autophagy and apoptosis. The YTH family plays a role in promoting ferroptosis, autophagy, and apoptosis according to mediate different target proteins.